ISSN 1662-4009 (online)

ey0019.14-5 | Steroidogenesis and beyond | ESPEYB19

14.5. Embryonic osteocalcin signalling determines lifelong adrenal steroidogenesis and homeostasis in the mouse

VK Yadav , JM Berger , P Singh , P Nagarajan , G Karsenty

J Clin Invest 2022;132(4):e153752 doi: 10.1172/JCI153752Brief summary: Using rodent and primate models, this study shows a classical endocrine feedback loop, where bone-derived osteocalcin enhances adrenal steroidogenesis, and the inactivation of osteocalcin signalling impairs adrenal growth and steroidogenesis.This study provides important evidence on the existence of the bo...